Pulmonary Hemosiderosis and Fibrosis in Trisomy 21

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Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21.

BACKGROUND It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids. METHODS We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years. The cytogenetic analysis r...

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A two-month-old male with past medical history of recurrent diarrhea and failure to thrive presented with persistent cough, tachypnea and high inflammatory markers despite antibiotic treatment for pneumonia. One week earlier our patient was diagnosed with bilateral pneumonia based on same symptoms as well as chest x-ray findings, and was started on Amoxicillin 80mg/kg/day. There was no fever. P...

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Food-Induced Pulmonary Hemosiderosis

A two-month-old male with past medical history of recurrent diarrhea and failure to thrive presented with persistent cough, tachypnea and high inflammatory markers despite antibiotic treatment for pneumonia. One week earlier our patient was diagnosed with bilateral pneumonia based on same symptoms as well as chest x-ray findings, and was started on Amoxicillin 80mg/kg/day. There was no fever. P...

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ژورنال

عنوان ژورنال: Chest

سال: 2016

ISSN: 0012-3692

DOI: 10.1016/j.chest.2016.08.1059